Macrophage modulation of dental pulp stem cell activity during tertiary dentinogenesis.

ABSTRACT: The interaction between immune cells and stem cells is important during tissue repair. Macrophages have been described as being crucial for limb regeneration and in certain circumstances have been shown to affect stem cell differentiation in vivo. Dentine is susceptible to damage as a result of caries, pulp infection and inflammation all of which are major problems in tooth restoration. Characterising the interplay between immune cells and stem cells is crucial to understand how to improve natural repair mechanisms. In this study, we used an in vivo damage model, associated with a macrophage and neutrophil depletion model to investigate the role of immune cells in reparative dentine formation. In addition, we investigated the effect of elevating the Wnt/β-catenin pathway to understand how

SUBMITTER: Neves VCM 

PROVIDER: S-EPMC7678850 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature