Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence.

ABSTRACT:

Background

There is an unmet need to identify novel mechanism-based prognostic genes associated with hepatocellular carcinoma (HCC) recurrence that can predict patient outcomes and provide therapeutic targets. This study aims to identify potential novel driver genes and mutations in HCC.

Methods

Single nucleotide variations (SNVs) contributing to HCC recurrence were identified using whole-exome sequencing of 5 DNA samples extracted from a single HCC patient with HBV-induced cirrhosis. SNVs were verified in primary HCC (n = 87), recurrent HCC (n = 34), and benign liver disease with cirrhosis tissues (n = 43). A candidate gene was identified, and its association and function in HCC development and recurrence were examined.

Results

177 SNVs were identified and 70 SNVs we

SUBMITTER: Chen X 

PROVIDER: S-EPMC7678939 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature