The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?

ABSTRACT: Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep disorders. We discuss the functional anatomy of the basal ganglia, and review evidence implicating their role in sleep. Whilst these studies are in their infancy, we suggest that the basal ganglia may play an integral role in the sleep-wake cycle, specifically by contributing to a thalamo-cortical-basal gang

SUBMITTER: Hasegawa H 

PROVIDER: S-EPMC7679363 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature