Identification and Validation of MSX1 as a Key Candidate for Progestin Resistance in Endometrial Cancer.

ABSTRACT:

Purpose

Progestin resistance is a critical obstacle for endometrial conservative therapy. Therefore, studies to acquire a more comprehensive understanding of the mechanisms are urgent. However, the pivotal molecules are still unexplored.

Materials and methods

We downloaded GSE121367 from the GEO database. The "limma" R language package was applied to identify differentially expressed genes (DEGs). We conducted Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA). Protein-protein interaction was constructed by STRING and visualized in Cytoscape. The tumor immune microenvironment was explored by the TISIDB database. Methylation validation and overall survival analysis were conducted by the TCGA database. In addition, the upstream modulators of hub genes w

SUBMITTER: Yang L 

PROVIDER: S-EPMC7679365 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature