Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome.

ABSTRACT:

Objectives

This study sought to determine the relationship between long QT syndrome (LQTS) subtype (LTQ1, LTQ2, LTQ3) and postnatal cardiac events (CEs).

Background

LQTS presenting with 2:1 atrioventricular block or torsades de pointes in the fetus and/or neonate has been associated with risk for major CEs, but overall outcomes and predictors remain unknown.

Methods

A retrospective study involving 25 international centers evaluated the course of fetuses/newborns diagnosed with congenital LQTS and either 2:1 atrioventricular block or torsades de pointes. The primary outcomes were age at first CE after dismissal from the newborn hospitalization and death and/or cardiac transplantation during follow-up. CE was defined as aborted cardiac arrest, appropriate shock from imp

SUBMITTER: Moore JP 

PROVIDER: S-EPMC7679474 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature