Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes.

ABSTRACT: The objective of this study was to compare the ratio of renal oxygen availability (RO₂) to glomerular filtration rate (GFR), a measure of relative renal hypoxia, in adolescents with and without type 1 diabetes (T1D) and relate the ratio to albuminuria, renal plasma flow (RPF), fat mass, and insulin sensitivity (M/I). RO₂ was estimated by blood oxygen level-dependent MRI; fat mass was estimated by DXA; GFR and RPF were estimated by iohexol and p-aminohippurate clearance; albuminuria was estimated by urine albumin-to-creatinine ratio (UACR); and M/I was estimated from steady-state glucose infusion rate/insulin (mg/kg/min) by hyperglycemic clamp in 50 adolescents with T1D (age 16.1 ± 3.0 years, HbA_1c 8.6 ± 1.2%) and 20 control patients of

SUBMITTER: Vinovskis C 

PROVIDER: S-EPMC7679770 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature