STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity.

ABSTRACT: Obesity fosters low-grade inflammation in white adipose tissue (WAT) that may contribute to the insulin resistance that characterizes type 2 diabetes. However, the causal relationship of these events remains unclear. The established dominance of STAT1 function in the immune response suggests an obligate link between inflammation and the comorbidities of obesity. To this end, we sought to determine how STAT1 activity in white adipocytes affects insulin sensitivity. STAT1 expression in WAT inversely correlated with fasting plasma glucose in both obese mice and humans. Metabolomic and gene expression profiling established STAT1 deletion in adipocytes (STAT1 ^a-KO ) enhanced mitochondrial function and accelerated tricarboxylic acid cycle flux coupled with reduced fat ce

SUBMITTER: Cox AR 

PROVIDER: S-EPMC7679774 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature