Wide QRS-T angles are associated with markers of increased inflammatory activity independently of hypertension and diabetes.

ABSTRACT:

Background

Wide QRS-T angles and inflammatory activity are markers of future cardiovascular events including sudden cardiac death (SCD). The association between wide QRS-T angles and inflammatory activation is however not fully understood.

Methods

1,094 study participants of both sexes, 50-64 years old, were included from a randomly selected population-based cohort as a part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot study. Serum samples were analyzed for markers of inflammation, cardiac wall stress/injury, and the metabolic syndrome. Wide QRS-T angles were defined using Frank vectorcardiography. Variables were analyzed through unsupervised principal component analysis (PCA) as well as Orthogonal Projections to Latent Structures (OPLS) modeling. In addition

SUBMITTER: Sandstedt M 

PROVIDER: S-EPMC7679831 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature