Cryo-electron microscopy structure of human ABCB6 transporter.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC7679968 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Cryo-electron microscopy structure of human ABCB6 transporter.
Wang Chunyu C Cao Can C Wang Nan N Wang Xiangxi X Wang Xianping X Zhang Xuejun C XC
Protein science : a publication of the Protein Society 20201015 12
Human ATP-binding cassette transporter 6 of subfamily B (ABCB6) is an ABC transporter involved in the translocation toxic metals and anti-cancer drugs. Using cryo-electron microscopy, we determined the molecular structure of full-length ABCB6 in an apo state. The structure of ABCB6 unravels the architecture of a full-length ABCB transporter that harbors two N-terminal transmembrane domains which is indispensable for its ATPase activity in our in vitro assay. A slit-like substrate binding pocket ...[more]
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