Microbial function and genital inflammation in young South African women at high risk of HIV infection.

ABSTRACT:

Background

Female genital tract (FGT) inflammation is an important risk factor for HIV acquisition. The FGT microbiome is closely associated with inflammatory profile; however, the relative importance of microbial activities has not been established. Since proteins are key elements representing actual microbial functions, this study utilized metaproteomics to evaluate the relationship between FGT microbial function and inflammation in 113 young and adolescent South African women at high risk of HIV infection. Women were grouped as having low, medium, or high FGT inflammation by K-means clustering according to pro-inflammatory cytokine concentrations.

Results

A total of 3186 microbial and human proteins were identified in lateral vaginal wall swabs using liquid chromatography

SUBMITTER: Alisoltani A 

PROVIDER: S-EPMC7679981 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature