Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting?

ABSTRACT: The translation of cardioprotection from robust experimental evidence to beneficial clinical outcome for patients suffering acute myocardial infarction or undergoing cardiovascular surgery has been largely disappointing. The present review attempts to critically analyse the evidence for confounders of cardioprotection in patients with acute myocardial infarction and in patients undergoing cardiovascular surgery. One reason that has been proposed to be responsible for such lack of translation is the confounding of cardioprotection by co-morbidities and co-medications. Whereas there is solid experimental evidence for such confounding of cardioprotection by single co-morbidities and co-medications, the clinical evidence from retrospective analyses of the limited number of clinical data is les

SUBMITTER: Kleinbongard P 

PROVIDER: S-EPMC7680006 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature