A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction.

ABSTRACT:

Background and purpose

Atherosclerosis, resulting from lipid dysregulation and vascular inflammation, causes atherosclerotic cardiovascular disease (ASCVD), which contributes to morbidity and mortality worldwide. Chalcone and its derivatives possess beneficial properties, including anti-inflammatory, antioxidant and antitumour activity with unknown cardioprotective effects. We aimed to develop an effective chalcone derivative with antiatherogenic potential.

Experimental approach

Human THP-1 cells and HUVECs were used as in vitro models. Western blots and real-time PCRs were performed to quantify protein, mRNA and miRNA expressions. The cholesterol efflux capacity was assayed by ³ H labelling of cholesterol. LDL receptor knockout (Ldlr^-/- ) mice fed a hi

SUBMITTER: Chen LW 

PROVIDER: S-EPMC7680011 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature