High affinity of host human microRNAs to SARS-CoV-2 genome: An in silico analysis.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) caused by a novel betacoronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has attracted top health concerns worldwide within a few months after its appearance. Since viruses are highly dependent on the host small RNAs (microRNAs) for their replication and propagation, in this study, top miRNAs targeting SARS-CoV-2 genome and top miRNAs targeting differentially expressed genes (DEGs) in lungs of patients infected with SARS-CoV-2, were predicted.

Methods

All human mature miRNA sequences were acquired from miRBase database. MiRanda tool was used to predict the potential human miRNA binding sites on the SARS-CoV-2 genome. EdgeR identified differentially expressed genes (DEGs) in response to SARS-CoV-2 infe

SUBMITTER: Jafarinejad-Farsangi S 

PROVIDER: S-EPMC7680021 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature