Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice.

ABSTRACT:

Background & aims

Nonalcoholic fatty liver disease (NAFLD) is the most common pediatric chronic liver disease. Little is known about outcomes in recognized youth.

Methods

We compared paired liver biopsies from 122 of 139 children with NAFLD (74% male; 64% white; 71% Hispanic; mean age, 13 ± 3 years; age range, 8-17 years) who received placebo and standard of care lifestyle advice in 2 double-blind, randomized clinical trials within the nonalcoholic steatohepatitis (NASH) clinical research network from 2005 through 2015. We analyzed histologic changes with respect to baseline and longitudinal change in clinical variables using regression analysis.

Results

At enrollment, 31% of the children had definite NASH, 34% had borderline zone 1 NASH, 13% had borderline zone 3 NAS

SUBMITTER: Xanthakos SA 

PROVIDER: S-EPMC7680281 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature