Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.

ABSTRACT:

Purpose

We aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), and their relationship with cognition in Alzheimer's disease (AD), by using a single dynamic [¹⁸F]flortaucipir positron emission tomography (PET) scan.

Methods

Seventy-one subjects with AD (66 ± 8 years, mini-mental state examination (MMSE) 23 ± 4) underwent a dynamic 130-min [¹⁸F]flortaucipir PET scan. Cognitive assessment consisted of composite scores of four cognitive domains. For tau pathology and rCBF, receptor parametric mapping (cerebellar gray matter reference region) was used to create uncorrected and partial volume-corrected parametric images of non-displaceable binding potential (BP_ND) and R₁, respectively. (Voxel-

SUBMITTER: Visser D 

PROVIDER: S-EPMC7680306 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature