Intestinal Epithelial TBK1 Prevents Differentiation of T-helper 17 Cells and Tumorigenesis in Mice.

ABSTRACT:

Background & aims

Intestinal epithelial cells (IECs) regulate intestinal immune cells, particularly development of T-helper 17 (Th17) cells. Deregulation of this process leads to intestinal inflammation and tumorigenesis, via unknown mechanisms. TANK-binding kinase 1 (TBK1) is expressed by IECs and cells in the innate immune system. We studied the functions of TBK1 in the intestinal immune response and tumorigenesis in mice.

Methods

We performed studies of wild-type mice, mice with conditional disruption of Tbk1 (Tbk1^IEC-KO), Tbk1^IEC-KO mice crossed with Apc^Min/+ mice, and Mt^-/- mice crossed with Apc^Min/+ mice. Some mice were given intraperitoneal injections of a neutralizing antibody against interleukin 17 (IL17) or IL1

SUBMITTER: Yang JY 

PROVIDER: S-EPMC7680348 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature