COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats.

ABSTRACT:

Background

Ethanol (EtOH) self-administration is particularly sensitive to the modulation of CB₁ signaling in the nucleus accumbens (NAc) shell, and EtOH consumption increases extracellular levels of the endogenous cannabinoid CB₁ receptor agonist 2-arachidonoyl glycerol (2-AG) in this brain region. Stimulation of CB₁ receptor with agonists increases EtOH consumption, suggesting that EtOH-induced increases in 2-AG might sustain motivation for EtOH intake.

Methods

In order to further explore this hypothesis, we analyzed the alterations in operant EtOH self-administration induced by intra-NAc shell infusions of 2-AG itself, the CB₁ inverse agonist SR141716A, the 2-AG clearance inhibitor URB602, anandamide, and the cyclooxygenase-2 (C

SUBMITTER: Pavon FJ 

PROVIDER: S-EPMC7680444 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature