Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes.

ABSTRACT:

Background

The prevalence of peripheral artery disease (PAD) is obviously increased in patients with diabetes. Existing evidence shows that cysteine-rich angiogenic inducer 61 (Cyr61), a 40-kD secreted protein, plays important roles in regulating cellular physiological processes. Recent studies have demonstrated a significant correlation between serum Cyr61 and atherosclerosis. However, the relationship between Cyr61 levels and PAD in patients with type 2 diabetes (T2DM) remains obscure.

Methods

Data from a total of 306 subjects with T2DM were cross-sectionally analysed. The extent of PAD was determined by using the Fontaine classification, which defines four stages. We measured serum Cyr61 concentrations by ELISA in subjects with and without PAD at Fontaine's stage II, III,

SUBMITTER: Feng B 

PROVIDER: S-EPMC7680586 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature