High cytoplasmic YAP1 expression predicts a poor prognosis in patients with colorectal cancer.

ABSTRACT:

Purpose

Yes associated protein 1 (YAP1), which is a standout amongst the most essential effectors of the Hippo pathway, assumes a vital part in a few kinds of cancer. However, whether YAP1 is an oncogene in CRC (colorectal cancer) remains controversial, and the association between the subcellular localization of YAP1 and clinical implications in CRC remains unknown.

Patients and methods

In this study, we investigated the subcellular localization of YAP1 in CRC cells by immunohistochemistry and then associate these findings with clinical information in a large CRC cohort with 919 CRC patients.

Results

The results show that CRC tissues has a significant higher expression of cytoplasmic YAP1 compared to adjacent normal tissues (all P < 0.001). Cytoplasmic YAP1 exp

SUBMITTER: Dong T 

PROVIDER: S-EPMC7680625 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature