Characterization of the hypoxia-inducible factor-1 pathway in hearts of Antarctic notothenioid fishes.

ABSTRACT: The ability of Antarctic notothenioid fishes to mount a robust molecular response to hypoxia is largely unknown. The transcription factor, hypoxia-inducible factor-1 (HIF-1), a heterodimer of HIF-1α and HIF-1β subunits, is the master regulator of oxygen homeostasis in most metazoans. We sought to determine if, in the hearts of Antarctic notothenioids, HIF-1 is activated and functional in response to either an acute heat stress or hypoxia. The red-blooded Notothenia coriiceps and the hemoglobinless icefish, Chaenocephalus aceratus, were exposed to their critical thermal maximum (CT_MAX) or hypoxia (5.0 ± 0.3 mg of O₂ L^-1) for 2 h. Additionally, N. coriiceps was exposed to 2.3 ± 0.3 mg of O₂ L^-1 for 12 h, and red-blooded Gobionotothen gib

SUBMITTER: O'Brien KM 

PROVIDER: S-EPMC7680639 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature