A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone.

ABSTRACT: Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling. Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling, its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated. In the present study, we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism. Absorbable collagen sponges containing 3 μg of recombinant human BMP2 (rhBMP2) were implanted in the dorsal muscle pouches of wild type (WT) and Smurf2^-/- mice. The rhBMP2-induced ectopic bone in Smu

SUBMITTER: Kushioka J 

PROVIDER: S-EPMC7680794 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature