Augmented Oscillations in QT Interval Duration Predict Mortality Post Myocardial Infarction Independent of Heart Rate.

ABSTRACT:

Objective

This study seeks to decompose QT variability (QTV) into physiological sources and assess their role for risk stratification in patients post myocardial infarction (MI). We hypothesize that the magnitude of QTV that cannot be explained by heart rate or respiration carries important prognostic information.

Background

Elevated beat-to-beat QTV is predictive of cardiac mortality, but the underlying mechanisms, and hence its interpretation, remain opaque.

Methods

We decomposed the QTV of 895 patients post MI into contributions by heart rate, respiration, and unexplained sources.

Results

Cox proportional hazard analysis demonstrates that augmented oscillations in QTV and their level of dissociation from heart rate are associated with a higher 5-year mortali

SUBMITTER: El-Hamad FJ 

PROVIDER: S-EPMC7680963 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature