Plasma proteomic profile of age, health span, and all-cause mortality in older adults.

ABSTRACT: Aging is a complex trait characterized by a diverse spectrum of endophenotypes. By utilizing the SomaScan^® proteomic platform in 1,025 participants of the LonGenity cohort (age range: 65-95, 55.7% females), we found that 754 of 4,265 proteins were associated with chronological age. Pleiotrophin (PTN; β[SE] = 0.0262 [0.0012]; p = 3.21 × 10^-86 ), WNT1-inducible-signaling pathway protein 2 (WISP-2; β[SE] = 0.0189 [0.0009]; p = 4.60 × 10^-82 ), chordin-like protein 1 (CRDL1; β[SE] = 0.0203[0.0010]; p = 1.45 × 10^-77 ), transgelin (TAGL; β[SE] = 0.0215 [0.0011]; p = 9.70 × 10^-71 ), and R-spondin-1(RSPO1; β[SE] = 0.0208 [0.0011]; p = 1.09 × 10^-70 ), were the proteins most significantly associated with age. Weighted gene co-expressio

SUBMITTER: Sathyan S 

PROVIDER: S-EPMC7681045 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature