Ontology highlight
ABSTRACT:
SUBMITTER: Wong CE
PROVIDER: S-EPMC7681104 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Wong Chia-En CE Jin Lee-Way LW Chu Yuan-Ping YP Wei Wei-Yen WY Ho Pei-Chuan PC Tsai Kuen-Jer KJ
Theranostics 20210101 1
<b>Background:</b> Local protein synthesis and mRNA metabolism mediated by mRNP granules in the dendrites and the postsynaptic compartment is essential for synaptic remodeling and plasticity in neuronal cells. Dysregulation of these processes caused by TDP-43 proteinopathy leads to neurodegenerative diseases, such as frontotemporal lobar degeneration and amyotrophic lateral sclerosis. <b>Methods:</b> Using biochemical analysis and imaging techniques, including super-resolution microscopy, we pro ...[more]