Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum.

ABSTRACT:

Aims

Psychosis spectrum disorder has a complex pathoetiology characterised by interacting environmental and genetic vulnerabilities. The present study aims to investigate the role of gene-environment interaction using aggregate scores of genetic (polygenic risk score for schizophrenia (PRS-SCZ)) and environment liability for schizophrenia (exposome score for schizophrenia (ES-SCZ)) across the psychosis continuum.

Methods

The sample consisted of 1699 patients, 1753 unaffected siblings, and 1542 healthy comparison participants. The Structured Interview for Schizotypy-Revised (SIS-R) was administered to analyse scores of total, positive, and negative schizotypy in siblings and healthy comparison participants. The PRS-SCZ was trained using the Psychiatric Genomics Consortiums re

SUBMITTER: Pries LK 

PROVIDER: S-EPMC7681168 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature