Network pharmacological systems study of Huang-Lian-Tang in the treatment of glioblastoma multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) has a poor prognosis and its recurrence and mortality rates are high. At present, there is no effective clinical method to control its progression and recurrence. Traditional Chinese Medicine has a high status not only in China, but also in the world. Certain drugs are also used in the clinical treatment of tumor diseases. In clinical practice, Huang-Lian-Tang (HLT) has proven efficacy in treating brain diseases and preventing tumor recurrence. However, the mechanisms of action have remained elusive. The present study explored the potential mechanisms of HLT in the treatment of gliomas based on network pharmacology. First, information on the composition of HLT was obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platfor

SUBMITTER: Liu W 

PROVIDER: S-EPMC7681198 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature