N⁶-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling.

ABSTRACT:

Background and aims

Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understanding these mechanisms will enhance the likelihood of effective sorafenib therapy.

Methods

In vitro and in vivo experiments were performed and clinical samples and online databases were acquired for clinical investigation.

Results

In this study, we found that a circular RNA, circRNA-SORE, which is up-regulated in sorafenib-resistant HCC cells, was necessary for the maintenance of sorafenib resistance, and that silencing circRNA-SORE substantially increased the efficacy of sorafenib-induced apoptosis. Mechanistic studies determined that circRNA-S

SUBMITTER: Xu J 

PROVIDER: S-EPMC7681956 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature