Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature.

ABSTRACT:

Background

Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in tumor-related immune processes which have become the most rapidly investigated area. Therefore, we aimed at developing an immune-related lncRNA signature to improve the prognosis prediction of breast cancer.

Methods

We obtained breast cancer patient samples and corresponding clinical data from The Cancer Genome Atlas (TCGA) database. Immune-related lncRNAs were screened by co-expression analysis of immune-related genes which were downloaded from the Immunology Database and Analysis Portal (ImmPort). Clinical patient samples were randomly separated into train

SUBMITTER: Ma W 

PROVIDER: S-EPMC7681988 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature