Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue.

ABSTRACT:

Introduction

Tau pathology is a major age-related event in Down syndrome with Alzheimer's disease (DS-AD). Although recently, several different Tau PET tracers have been developed as biomarkers for AD, these tracers showed different binding properties in Alzheimer disease and other non-AD tauopathies. They have not been yet investigated in tissue obtained postmortem for DS-AD cases. Here, we evaluated the binding characteristics of two Tau PET tracers (³H-MK6240 and ³H-THK5117) and one amyloid (³H-PIB) ligand in the medial frontal gyrus (MFG) and hippocampus (HIPP) in tissue from adults with DS-AD and DS cases with mild cognitive impairment (MCI) compared to sporadic AD.

Methods

Tau and amyloid autoradiography were performed on paraffin-embed

SUBMITTER: Lemoine L 

PROVIDER: S-EPMC7682014 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature