Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection.

ABSTRACT:

Background

Genetic factors may influence the susceptibility to high-risk (hr) human papillomavirus (HPV) infection and persistence. We conducted the first genome-wide association study (GWAS) to identify variants associated with cervical hrHPV infection and persistence.

Methods

Participants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF₁₀/LiPA₂₅. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) a

SUBMITTER: Adebamowo SN 

PROVIDER: S-EPMC7682060 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature