Characteristics of cytokines in the sciatic nerve stumps and DRGs after rat sciatic nerve crush injury.

ABSTRACT:

Background

Cytokines are essential cellular modulators of various physiological and pathological activities, including peripheral nerve repair and regeneration. However, the molecular changes of these cellular mediators after peripheral nerve injury are still unclear. This study aimed to identify cytokines critical for the regenerative process of injured peripheral nerves.

Methods

The sequencing data of the injured nerve stumps and the dorsal root ganglia (DRGs) of Sprague-Dawley (SD) rats subjected to sciatic nerve (SN) crush injury were analyzed to determine the expression patterns of genes coding for cytokines. PCR was used to validate the accuracy of the sequencing data.

Results

A total of 46, 52, and 54 upstream cytokines were differentially expressed in the SNs

SUBMITTER: Zhang RR 

PROVIDER: S-EPMC7682062 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature