Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS).

ABSTRACT:

Background

A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed, how often the exposure to new drugs leads to new sensitization or drug-related relapses without detectable sensitization.

Methods

46 patients with DRESS treated in the allergy division of the Inselspital, Bern University Hospital, were retrospectively assessed. Drug-related relapses were analyzed in terms of frequency and whether a possible sensitization evaluated by skin tests and/or lymphocyte transformation tests (LTT) to the new drugs was detectable. Furt

SUBMITTER: Jorg L 

PROVIDER: S-EPMC7682085 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature