Multiparametric MR-PET measurements in hypermetabolic regions reflect differences in molecular status and tumor grade in treatment-naive diffuse gliomas.

ABSTRACT:

Purpose

To assess whether hypermetabolically-defined regions of interest (ROIs) on 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (PET) could be used to evaluate physiological features and whether there are measurable differences between molecular subtypes and tumor grades.

Methods

Sixty-eight treatment-naïve glioma patients who underwent FDOPA PET and magnetic resonance imaging (MRI) were retrospectively included. Fluid-attenuated inversion recovery hyperintense regions (FLAIR_ROI) were segmented. FDOPA hypermetabolic regions (FDOPA_ROI, tumor-to-striatum ratios > 1) within FLAIR_ROI were extracted. Normalized maximum standardized uptake value (nSUV_max), volume of each ROI, and median relative cereb

SUBMITTER: Tatekawa H 

PROVIDER: S-EPMC7682113 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature