Risk of malignancies in patients with inflammatory bowel disease who used thiopurines as compared with other indications: a territory-wide study.

ABSTRACT:

Aims

Thiopurines are believed to increase cancer risks, but data from Asian patients are sparse. We determined the risks of malignancies in thiopurine users with inflammatory bowel disease (IBD) or other indications from Hong Kong.

Methods

All patients who had received thiopurines between 2005 and 2009 in Hong Kong were identified from local electronic healthcare database. Patients were followed from the start date of thiopurines until death or end of study in 2017. We excluded patients with baseline malignancy. Standardized incidence ratios (SIR) and the corresponding 95% confidence intervals (CI) of all malignancies were computed against matched local general population from the cancer registry. Patients in the same diagnosis category but not exposed to thiopurines were in

SUBMITTER: Zheng KYC 

PROVIDER: S-EPMC7682226 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature