Ontology highlight
ABSTRACT:
SUBMITTER: Foley AR
PROVIDER: S-EPMC7682355 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Foley Alejandro R AR Roseman Graham P GP Chan Ka K Smart Amanda A Finn Thomas S TS Yang Kevin K Lokey R Scott RS Millhauser Glenn L GL Raskatov Jevgenij A JA
Proceedings of the National Academy of Sciences of the United States of America 20201102 46
Evidence linking amyloid beta (Aβ) cellular uptake and toxicity has burgeoned, and mechanisms underlying this association are subjects of active research. Two major, interconnected questions are whether Aβ uptake is aggregation-dependent and whether it is sequence-specific. We recently reported that the neuronal uptake of Aβ depends significantly on peptide chirality, suggesting that the process is predominantly receptor-mediated. Over the past decade, the cellular prion protein (PrP<sup>C</sup> ...[more]