Vibrio cholerae adapts to sessile and motile lifestyles by cyclic di-GMP regulation of cell shape.

ABSTRACT: The cell morphology of rod-shaped bacteria is determined by the rigid net of peptidoglycan forming the cell wall. Alterations to the rod shape, such as the curved rod, occur through manipulating the process of cell wall synthesis. The human pathogen Vibrio cholerae typically exists as a curved rod, but straight rods have been observed under certain conditions. While this appears to be a regulated process, the regulatory pathways controlling cell shape transitions in V. cholerae and the benefits of switching between rod and curved shape have not been determined. We demonstrate that cell shape in V. cholerae is regulated by the bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) by posttranscriptionally repressing expression of crvA, a gen

SUBMITTER: Fernandez NL 

PROVIDER: S-EPMC7682387 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature