A molecular docking study of EGCG and theaflavin digallate with the druggable targets of SARS-CoV-2.

ABSTRACT:

Background

COVID-19 is an infectious disease caused by a novel positive-sense single-stranded RNA coronavirus called as SARS-CoV-2. This viral disease is known to infect the respiratory system, eventually leading to pneumonia. Crystallographic studies of the viral structure reveal its mechanism of infection as well as active binding sites and the druggable targets as scope for treatment of COVID-19.

Hypothesis

The role of tea polyphenols in prophylaxis and treatment of COVID-19 was established in this study.

Study design

Molecular docking interactions of tea polyphenols with some of the possible binding sites of SARS-CoV-2 were performed.

Materials and methods

From various studies on the SARS-CoV-2 reported in the literature, we chose possible drug targets (Chy

SUBMITTER: Mhatre S 

PROVIDER: S-EPMC7682485 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature