Multicentre feasibility of multiple-breath washout in preschool children with cystic fibrosis and other lung diseases.

ABSTRACT:

Background

Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects early cystic fibrosis (CF) lung disease. LCI was used as an end-point in single- and multicentre settings at highly experienced MBW centres in preschool children. However, multicentre feasibility of MBW in children aged 2-6 years, including centres naïve to this technique, has not been determined systematically.

Methods

Following central training, 91 standardised nitrogen MBW investigations were performed in 74 awake preschool children (15 controls, 46 with CF, and 13 with other lung diseases), mean age 4.6±0.9 years at investigation, using a commercially available device across five centres in Germany (three experienced, two naïve to the performance in awake preschool children) with central

SUBMITTER: Stahl M 

PROVIDER: S-EPMC7682699 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature