Registry-based trials: a potential model for cost savings?

ABSTRACT:

Background/aims

Registry-based trials have emerged as a potentially cost-saving study methodology. Early estimates of cost savings, however, conflated the benefits associated with registry utilisation and those associated with other aspects of pragmatic trial designs, which might not all be as broadly applicable. In this study, we sought to build a practical tool that investigators could use across disciplines to estimate the ranges of potential cost differences associated with implementing registry-based trials versus standard clinical trials.

Methods

We built simulation Markov models to compare unique costs associated with data acquisition, cleaning, and linkage under a registry-based trial design versus a standard clinical trial. We conducted one-way, two-way, and probabi

SUBMITTER: Anderson BR 

PROVIDER: S-EPMC7682727 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature