The miRNA 196a2 rs11614913 variant has prognostic impact on Turkish patients with multiple myeloma.

ABSTRACT:

Objective

Multiple myeloma (MM) arises from malignant plasma cells as a single clone in the bone marrow. Accumulating evidences have reported that there is an association between miR-196a2 (rs11614913) variant and various cancers while there were unverified and inconsistent results in MM. The goal of this study is to investigate the impact of the miR-196a2 variant on clinical findings and susceptibility in MM. Two hundred MM patients (156 patients under transplantation of autologous stem cell) and 200 healthy controls included in this study.

Results

The statistical analysis showed no significant relationship for allele and frequencies of miR-196a2 genotype between patients and controls (p > 0.05). Log-rank test showed that gender has highly significant impact on both OS and

SUBMITTER: Kirik MP 

PROVIDER: S-EPMC7682760 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature