Structural and functional brain connectome in motor neuron diseases: A multicenter MRI study.

ABSTRACT:

Objective

To investigate structural and functional neural organization in amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and progressive muscular atrophy (PMA).

Methods

A total of 173 patients with sporadic ALS, 38 patients with PLS, 28 patients with PMA, and 79 healthy controls were recruited from 3 Italian centers. Participants underwent clinical, neuropsychological, and brain MRI evaluations. Using graph analysis and connectomics, global and lobar topologic network properties and regional structural and functional brain connectivity were assessed. The association between structural and functional network organization and clinical and cognitive data was investigated.

Results

Compared with healthy controls, patients with ALS and patients with P

SUBMITTER: Basaia S 

PROVIDER: S-EPMC7682834 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature