Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study.

ABSTRACT:

Objective

To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD).

Methods

We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (n = 446,118), Psychiatric Genomics Consortium (n = 18,759), and International Genomics of Alzheimer's Project (n = 63,926). We used the inverse variance-weighted Mendelian randomization method to estimate causal effects and weighted median and Mendelian randomization-Egger for sensitivity analyses to test for pleiotropic effects.

Results

We found that higher risk of AD was significantly associated with being a "morning person" (odds ratio [OR] 1.01, p<

SUBMITTER: Huang J 

PROVIDER: S-EPMC7682841 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature