Autoantibodies against the prion protein in individuals with PRNP mutations.

ABSTRACT:

Objective

To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease.

Methods

In this case-control study, we collected 124 blood samples from individuals with a variety of pathogenic PRNP mutations and 78 control individuals with a positive family history of genetic prion disease but lacking disease-associated PRNP mutations. Antibody reactivity was measured using an indirect ELISA for the detection of human immunoglobulin G_1-4 antibodies against wild-type human prion protein. Multivariate linear regression models were constructed to analyze differences in autoantibody reactivity between (1)

SUBMITTER: Frontzek K 

PROVIDER: S-EPMC7682844 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature