Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.

ABSTRACT:

Objective

To investigate the association between APOE genotype and β-amyloid (Aβ) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease-related cognitive impairment (ADCI).

Methods

This was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of APOE genotype or diagnostic group on Aβ positivity, we performed multivariate logistic regression analyses. Further distinctive underlying features of latent subgroups were examined by employing a latent class cluster analysis approach.

Results

In comparison with ε3 homozygotes, in the ADCI group, ε2 carriers showed a lower frequency of Aβ positivity (odds ratio [OR] 0.43, 95% confidence interval [CI] 0

SUBMITTER: Lee JS 

PROVIDER: S-EPMC7682916 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature