Plasma lipidomic profiling identifies a novel complex lipid signature associated with ischemic stroke in chronic kidney disease.

ABSTRACT:

Rationale and objective

Despite contribution of dyslipidemia to ischemic stroke, plasma lipidomic correlates of stroke in CKD is not studied. This study is aimed to identify plasma lipid alterations associated with stroke.

Study design

Cross sectional.

Setting and population

214 participants of Clinical Phenotyping and Resource Biobank Core (CPROBE). Clinical data and plasma samples at the time of recruitment were obtained and used to generate lipidomic data by liquid chromatography/mass-spectrometry-based untargeted platform.

Predictors

Various levels of free fatty acids, acylcarnitines and complex lipids.

Outcome

Stroke.

Analytic approach

includes compound by compound comparison of lipids using t-test adjusted by false discovery rate in patients

SUBMITTER: Afshinnia F 

PROVIDER: S-EPMC7682927 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature