Targeting Viral DNA and Promoter Hypermethylation in Salivary Rinses for Recurrent HPV-Positive Oropharyngeal Cancer.

ABSTRACT:

Objective

The incidence and survivorship of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) are increasing. Presence of HPV DNA and epigenetic alterations in salivary rinses are independently associated with clinical prognosis. We evaluated the utility of a combined panel in detecting disease recurrence during surveillance. We also assessed the assay's applicability in screening for HPV+ OPSCC.

Study design

Retrospective cohort study.

Setting

Two tertiary academic hospitals.

Subjects and methods

Forty-nine patients with posttreatment OPSCC were enrolled. Separately, 21 treatment-naive patients and 40 controls were included in the screening analysis. Salivary rinses were obtained from these cohorts and biomarker levels were qu

SUBMITTER: Shen S 

PROVIDER: S-EPMC7683010 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature