Patterns of Regional Cerebral Blood Flow as a Function of Obesity in Adults.

ABSTRACT:

Background

While obesity has been shown to be a risk factor for Alzheimer's disease, the potential mechanisms underlying this risk may be clarified with better understanding of underlying physiology in obese persons.

Objective

To identify patterns of cerebral perfusion abnormality in adults as a function of body mass index (BMI) defined weight categories, including overweight or obese status.

Methods

A large psychiatric cohort of 35,442 brain scans across 17,721 adults (mean age 40.8±16.2 years, range 18-94 years) were imaged with SPECT during baseline and concentration scans, the latter done after each participant completed the Connors Continuous Performance Test II. ANOVA was done to identify patterns of perfusion abnormality in this cohort across BMI designations o

SUBMITTER: Amen DG 

PROVIDER: S-EPMC7683049 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature