An Operational Definition of 'Abnormal Cognition' to Optimize the Prediction of Progression to Dementia: What Are Optimal Cut-Off Points for Univariate and Multivariate Normative Comparisons?

ABSTRACT:

Background

In neuropsychology and neurology, there is no consensus on the definition of abnormal cognition.

Objective

To operationally define 'abnormal cognition' for optimally predicting progression to dementia in a memory clinic sample, and to test whether multivariate profile analysis of cognitive test results improves this prediction compared to standard clinical evaluation.

Methods

We used longitudinal data from 835 non-demented patients of the Amsterdam Dementia Cohort. For 10 cognitive measures at baseline, we determined which number of abnormal tests and which magnitude of score deviations best predicted progression.

Results

Predictive ability for progression to dementia of one, two, and three abnormal test scores out of 10 is highly similar (Cox hazard

SUBMITTER: de Vent NR 

PROVIDER: S-EPMC7683061 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature