Allelic Distribution of Genes for Apolipoprotein E and MTHFR in Patients with Alzheimer's Disease and Their Epistatic Interaction.

ABSTRACT:

Background

Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). However, the gene-gene interaction (epistasis) between specific allelic variants is only partially understood.

Objective

In our study, we examined the presence of the ɛ4 allele of apolipoprotein E (APOE) and the presence of C677T and A1298C (rs1801133 and rs1801131) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with AD and controls. We also evaluated the epistatic interaction between MTHFR and the APOE variants.

Methods

A total of 564 patients with AD and 534 cognitively unimpaired age-matched controls were involved in the study.

Results

The presence of the ɛ4 allele of APOE increases the risk of developing AD in a dose-dep

SUBMITTER: Sutovsky S 

PROVIDER: S-EPMC7683064 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature