The Clinical Non-Motor Connectome in Early Parkinson's Disease.

ABSTRACT:

Background

Non-motor symptoms (NMS) of various anatomical origins are seen in early stage idiopathic Parkinson's disease (IPD).

Objective

To analyse when and how NMS are linked together at this stage of the disease.

Methods

Prospective study recruiting 64 IPD patients with ≤3 years of disease duration and 71 age-matched healthy controls (HC). NMS were clustered in 7 non-motor domains (NMD): general cognition, executive function, visuospatial function, autonomic function, olfaction, mood, and sleep. Correlation coefficients ≥|0.3| were considered as significant. Bootstrapped correlation coefficients between the scores were generated in both groups. Fourteen IPD patients and 19 HC were available for a follow-up study two years later.

Results

The mean age of both

SUBMITTER: Diederich NJ 

PROVIDER: S-EPMC7683075 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature